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Impact of Prior Statin Therapy on 1-year Recurrence and Length of Hospitalization for Acute Idiopathic Pericarditis

William Nseir1, Lior Masika2, Adi Sharabi-Nov3

  • 1Department of Internal Medicine A, Padeh Medical Center, Poriya, Israel, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

The Israel Medical Association Journal : IMAJ
|November 27, 2022
PubMed

Insights

Prior statin use in patients with acute idiopathic pericarditis (AIP) did not reduce 1-year recurrence but was associated with a longer length of hospitalization (LOH). Further research is needed to understand these findings in AIP patients.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Statins possess anti-inflammatory properties beyond lipid reduction.
  • Acute idiopathic pericarditis (AIP) is an inflammatory condition of the pericardium.

Purpose of the Study:

  • To investigate the impact of prior statin therapy on the clinical course of a first episode of AIP.
  • Specifically, to assess effects on 1-year recurrence rates and length of hospitalization (LOH).

Main Methods:

  • Retrospective study of 148 patients with a first episode of AIP (2015-2019).
  • Patients were divided into two groups: those without statin use (n=117) and those with prior statin use (n=31).
  • Comparison included age, comorbidities, laboratory data, 1-year recurrence, and LOH.

Main Results:

  • Patients with prior statin use were significantly older (64.4 vs. 37.5 years, P < 0.01).
  • Prior statin use was not associated with a reduced 1-year recurrence of pericarditis (P = 0.95).
  • However, prior statin use was linked to a prolonged length of hospitalization (LOH) (P = 0.01).

Conclusions:

  • Prior statin therapy does not appear to decrease the 1-year recurrence rate in patients experiencing their first episode of AIP.
  • Conversely, statin use was associated with an increased length of hospitalization in this patient cohort.
Abstract

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