Increase in different peripheral effector T subsets in acute and chronic gout
Li-Jun Zhao1, Hui Wang1, Hui-Ying Gao1
1Department of Rheumatology, The Second Hospital of Shanxi Medical University, 030013 Taiyuan, Shanxi, China.
Transplant Immunology
|November 27, 2022
Summary
Gout patients show altered T helper cell subsets, with increased Th1 cells and evolving Th17 involvement as the disease progresses. This highlights immune system changes in gout pathogenesis.
Area of Science:
- Immunology
- Rheumatology
- Metabolic Disorders
Background:
- Gout is a purine metabolic disorder causing inflammatory joint disease due to uric acid deposition.
- The precise role of the immune system, particularly T cell subsets, in gout pathogenesis remains incompletely understood.
Purpose of the Study:
- To investigate alterations in peripheral CD4+ T cell subsets in patients with acute and chronic gout.
- To explore the relationship between these T cell subsets and disease progression and clinical indicators.
Main Methods:
- Analysis of peripheral CD4+ T lymphocyte subsets using modified flow cytometry in 205 gout patients and 87 healthy controls.
- Collection of clinical indicators, immune function data, and medical history.
Main Results:
- Gout patients exhibited increased T helper 1 (Th1) cell counts compared to healthy controls.
- Chronic gout patients showed higher Th1 cell counts and Th1/Th2 ratios, and lower Th2 cell ratios compared to acute gout patients.
- Th1 and Th17 cell counts negatively correlated with C-reactive protein (CRP) levels; disease duration was an independent risk factor for chronic gout.
Conclusions:
- The balance of Th1 and Th2 cells is implicated throughout all stages of gout.
- Th17 cells become involved in gout as the disease progresses, suggesting a dynamic immune response.
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