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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: Aug 19, 2025

Augmented Reality Navigation-Guided Core Decompression for Osteonecrosis of Femoral Head
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ACR Appropriateness Criteria® Osteonecrosis: 2022 Update.

, Alice S Ha1, Eric Y Chang2

  • 1Panel Vice-Chair, University of Washington, Seattle, Washington.

Journal of the American College of Radiology : JACR
|November 27, 2022
PubMed
Summary
This summary is machine-generated.

Osteonecrosis, or bone death from poor blood supply, affects adults and has many risk factors. Early diagnosis and imaging are crucial for preventing joint collapse and guiding treatment.

Keywords:
AUCAppropriate Use CriteriaAppropriateness CriteriaAvascular necrosisFemoral headHumeral headOsteonecrosisTalus

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Area of Science:

  • Orthopedics
  • Radiology
  • Pathology

Background:

  • Osteonecrosis, also known as avascular or aseptic necrosis, is bone death due to insufficient blood supply.
  • It commonly affects adults aged 30-50 and impacts sites like the femoral head, humeral head, and talus.
  • Numerous risk factors contribute, including trauma, corticosteroid use, alcohol, HIV, and certain diseases.

Framework:

  • The American College of Radiology (ACR) Appropriateness Criteria provide evidence-based guidelines for medical imaging in specific clinical conditions.
  • These guidelines are developed and revised annually by a multidisciplinary expert panel, utilizing systematic analysis of peer-reviewed literature.
  • Methodologies like Grading of Recommendations Assessment, Development, and Evaluation (GRADE) and the RAND/UCLA Appropriateness Method inform the guideline development process.

Implementation:

  • Early diagnosis of osteonecrosis is crucial for differentiating it from other causes of pain and for implementing timely surgical interventions.
  • Imaging plays a vital role in the early detection of osteonecrosis, aiding in preoperative planning and potentially preventing joint collapse.
  • In cases with limited or equivocal literature, expert opinion serves as a primary source for formulating recommendations within the ACR Appropriateness Criteria.

Implications:

  • Accurate and timely diagnosis of osteonecrosis through appropriate imaging can prevent severe complications such as subchondral fracture and secondary osteoarthritis.
  • Effective management strategies guided by evidence-based criteria can help avoid joint replacement surgeries.
  • The ACR Appropriateness Criteria facilitate standardized, evidence-based approaches to imaging for osteonecrosis, improving patient outcomes and optimizing resource utilization.