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"Nutrient-Repositioning"-Unexpected Amino Acid Functions
Yasuyuki Kitaura1, Kohsuke Hayamizu2, Eri Wada3
1Graduate School of Bioagricultural Sciences, Nagoya University.
Journal of Nutritional Science and Vitaminology
|November 27, 2022
Summary
Nutrient repositioning discovers new therapeutic uses for nutrients beyond their nutritional value. This review highlights unexpected functions of amino acids, including BCAAs, histidine, and serine, in novel health applications.
Area of Science:
- Biochemistry
- Pharmacology
- Nutritional Science
Background:
- Drug repositioning identifies new therapeutic applications for existing drugs.
- Nutrients, like drugs, can serve both nutritional and therapeutic roles.
- Amino acids are fundamental protein building blocks with emerging therapeutic potential.
Approach:
- Introduce the concept of "nutrient-repositioning" for discovering novel nutrient functions.
- Review recent scientific findings on unexpected amino acid activities.
- Focus on branched-chain amino acids (BCAAs), histidine, and serine.
Key Points:
- Amino acids demonstrate therapeutic effects beyond basic nutrition.
- Branched-chain amino acids (BCAAs) exhibit previously unrecognized health benefits.
- Histidine and serine show promise in novel therapeutic applications.
Conclusions:
- Nutrient repositioning offers a new paradigm for therapeutic discovery.
- Amino acids represent a promising class of compounds for "nutrient-repositioning" strategies.
- Further research into unexpected amino acid functions can lead to innovative health solutions.
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