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The role of TIGAR in nervous system diseases

Bei Huang1,2, Xiaoling Lang1,2, Xihong Li1,2

  • 1West China Second University Hospital, Sichuan University, Chengdu, China.

Frontiers in Aging Neuroscience
|November 28, 2022
PubMed

Insights

TP53-induced glycolysis and apoptosis regulator (TIGAR) is crucial for DNA repair and cell homeostasis. This review explores TIGAR

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Neuroscience

Background:

  • TP53-induced glycolysis and apoptosis regulator (TIGAR) plays a key role in the pentose phosphate pathway.
  • TIGAR regulates glycolysis to provide ribose for DNA synthesis and repair.
  • Its functions include anti-oxidative stress, anti-inflammation, and maintaining mitochondrial function.

Purpose of the Study:

  • To review the role of TIGAR in various neurological diseases.
  • To highlight TIGAR's potential as a therapeutic target in neurology.

Main Methods:

  • Literature review of TIGAR's involvement in neurological conditions.
  • Analysis of TIGAR's physiological functions relevant to brain health.

Main Results:

  • TIGAR's involvement in stroke, Parkinson's disease, Alzheimer's disease, seizures, and brain tumors is discussed.
  • TIGAR's protective mechanisms against neuronal damage are examined.

Conclusions:

  • TIGAR is a significant regulator with diverse protective roles in the nervous system.
  • Further research into TIGAR may lead to novel therapeutic strategies for neurological disorders.
Keywords:
ADPDTIGARbrain tumorsnervous system diseasesseizuresstroke

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