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Association Between Aldosterone and Hypertension Among Patients With Overt and Subclinical Hypercortisolism
Kosuke Inoue1,2, Hirofumi Horikoshi2, Masao Omura2
1Department of Social Epidemiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8315, Japan.
Journal of the Endocrine Society
|November 28, 2022
Summary
Aldosterone may contribute to hypertension in patients with subclinical hypercortisolism. Higher plasma aldosterone concentrations were linked to elevated blood pressure and improved hypertension post-adrenalectomy in these patients.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
Background:
- Hypertension is a common feature of hypercortisolism.
- The role of aldosterone in hypercortisolism-related hypertension is not fully understood.
Purpose of the Study:
- To investigate the association between plasma aldosterone concentrations (PACs) and hypertension in patients with overt and subclinical hypercortisolism.
- To determine if PACs predict hypertension improvement after adrenalectomy.
Main Methods:
- Retrospective cohort study of 89 patients with adrenal tumors and elevated cortisol levels.
- Multivariable regression analysis to assess PACs' association with systolic blood pressure and postoperative hypertension.
- Analysis included patients with overt and subclinical hypercortisolism.
Main Results:
- Higher PACs were significantly associated with elevated systolic blood pressure in patients with subclinical hypercortisolism (P=0.008).
- No significant association was found between PACs and blood pressure in overt hypercortisolism.
- Higher baseline PACs predicted improved hypertension after adrenalectomy in subclinical hypercortisolism patients (P=0.01).
Conclusions:
- Aldosterone may play a role in hypertension among patients with subclinical hypercortisolism.
- Further research is needed to validate these findings and explore aldosterone-targeted interventions.
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