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Thyroglobulin Assay Interferences: Clinical Usefulness of Mass-Spectrometry Methods

Giuseppe Barbesino1, Alicia Algeciras-Schimnich2, Joshua Bornhorst2

  • 1Thyroid Unit, Massachusetts General Hospital-Harvard Medical School, Boston, MA 02114, USA.

Journal of the Endocrine Society
|November 28, 2022
PubMed
Summary

Thyroglobulin mass spectrometry (TgMS) can identify heterophilic antibody interference, which causes falsely elevated thyroglobulin immunometric assays (TgIMA). However, TgMS may not detect structural disease in patients with thyroglobulin autoantibodies (TgAb).

Keywords:
TgAbheterophilic antibodyimmunometric assaysmass spectrometrythyroglobulinthyroglobulin antibodythyroid cancer

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