High-Risk HPV Genotype Distribution According to Cervical Cytology and Age

Area of Science:

• Gynecology
• Virology
• Public Health

Background:

• Retrospective analysis of cervical specimens from US patients.
• Investigated high-risk human papillomavirus (HPV) genotype distribution.
• Examined distribution based on cervical cytology and patient age.

Purpose of the Study:

• To determine the prevalence and distribution of high-risk HPV genotypes.
• To correlate HPV genotypes with cervical cytology results and patient demographics.
• To inform cervical cancer screening and prevention strategies.

Main Methods:

• Analysis of anonymous results from 23,580 patients' cervical specimens.
• Testing conducted between August 2020 and August 2021.
• Included cervical cytology and HPV testing.

Main Results:

• 9.8% of patients tested positive for high-risk HPV.
• Most frequent genotypes: HPV 52 (1.4%), HPV 39 (1.3%), HPV 51 (1.3%), and HPV 16 (1.2%).
• Highest HPV detection rates in patients under 25 years old (24.6% in <21, 25.4% in 21-25).
• Specific genotypes linked to lesion severity: HPV 51/39 in low-grade, HPV 16/52 in high-grade squamous intraepithelial lesions.

Conclusions:

• HPV genotyping and cytology data are crucial for cervical cancer screening.
• Findings can inform and enhance HPV vaccination programs.
• Understanding genotype distribution aids in targeted prevention efforts.