Artificial Intelligence Based Study Association between p53 Gene Polymorphism and Endometriosis: A Systematic Review...

Area of Science:

• Genetics
• Oncology
• Reproductive Medicine

Background:

• The tumor suppressor P53 gene is crucial in cancer development.
• Existing research suggests a link between the P53 gene and endometriosis risk, but findings are inconsistent.
• This study investigates the association between the P53 rs1042522 single nucleotide polymorphism and endometriosis incidence.

Approach:

• A meta-analysis was conducted to consolidate existing clinical data.
• A comprehensive literature search was performed across major scientific databases (PubMed, MEDLINE, EMBASE, Springer, Web of Science).
• Eight relevant studies with a total of 2991 participants (1551 cases, 1440 controls) were included and analyzed using Revman5.3.

Key Points:

• Meta-analysis revealed significant differences in GG gene frequency (OR=0.56) and allele C (OR=0.62) between endometriosis patients and controls.
• Allele G showed a significant association with increased endometriosis risk (OR=2.46).
• No significant differences were observed for GC and CC gene frequencies.

Conclusions:

• A significant correlation exists between P53 gene single nucleotide polymorphism and endometriosis incidence.
• Reduced GG gene frequency and increased allele C are associated with a higher risk of endometriosis.
• These findings highlight the potential role of P53 gene variations in endometriosis pathogenesis.