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Case report: Reversible encephalopathy associated with liposomal amphotericin B in a patient with cryptococcal
Si Luo1, Han Wen1, Meihong Zhou1
1Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Abstract:
Liposomal amphotericin B (L-AMB) is an anti-fungus medicine that has fewer side effects than traditional amphotericin B (AMB). Neurotoxicity of L-AMB has rarely been observed, and only one case of leukoencephalopathy during intravenous L-AMB has been reported. Herein, we described a patient with cryptococcal meningitis presenting with late-onset reversible encephalopathy associated with liposomal amphotericin B.
Insights
Liposomal amphotericin B (L-AMB) is an antifungal drug. This study reports a rare case of reversible encephalopathy in a patient with cryptococcal meningitis treated with L-AMB.
Area of Science:
- Neuroscience
- Infectious Diseases
- Pharmacology
Background:
- Liposomal amphotericin B (L-AMB) is a widely used antifungal agent known for its improved safety profile compared to conventional amphotericin B (AMB).
- Neurotoxicity is an uncommon adverse effect associated with L-AMB, with limited documented cases, primarily leukoencephalopathy.
Observation:
- A patient diagnosed with cryptococcal meningitis developed neurological symptoms.
- The patient was undergoing treatment with intravenous liposomal amphotericin B.
Findings:
- The patient exhibited late-onset, reversible encephalopathy.
- The neurological symptoms were temporally associated with the administration of liposomal amphotericin B.
Implications:
- This case highlights a rare but significant neurotoxic adverse effect of liposomal amphotericin B.
- Clinicians should remain vigilant for potential neurological complications in patients receiving L-AMB, even in late stages of treatment.
- Further investigation into the mechanisms of L-AMB-induced neurotoxicity may be warranted.
