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Updated: Aug 19, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Brain microstructural changes and fatigue after COVID-19.

Diógenes Diego de Carvalho Bispo^1,2,3, Pedro Renato de Paula Brandão^4,5, Danilo Assis Pereira⁶

¹Diagnostic Imaging Unit, Brasilia University Hospital, University of Brasilia, Brasília, Brazil.

Frontiers in Neurology

|November 28, 2022

Summary

This summary is machine-generated.

Post-COVID-19 patients show white matter microstructural changes, impacting fatigue and cognitive function. These brain alterations suggest a biological basis for persistent symptoms following SARS-CoV-2 infection.

Keywords:

COVID-19 brain cognition diffusion magnetic resonance imaging fatigue

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Area of Science:

Neuroscience
Radiology
Infectious Diseases

Background:

Persistent fatigue and cognitive issues are common after SARS-CoV-2 infection.
This study investigated brain changes in patients with mild-to-moderate COVID-19.

Purpose of the Study:

To assess fatigue and neuropsychological performance.
To investigate gray matter (GM) and white matter (WM) changes using MRI in COVID-19 survivors.

Main Methods:

56 COVID-19 patients and 37 controls underwent MRI scans.
Cognitive function and fatigue were assessed using standardized tests (MoCA, CAMBAT, CFQ-11).
Diffusion-weighted MRI (d-MRI) analyzed WM microstructure (FD) and T1-weighted MRI assessed GM volume/thickness.

Main Results:

COVID-19 patients reported significantly higher fatigue (CFQ-11 scores).
No significant differences in overall neuropsychological performance were observed between groups.
Reduced fiber density (FD) was found in multiple WM tracts in COVID-19 patients, correlating with fatigue and cognitive test results.

Conclusions:

Quantitative d-MRI revealed WM microstructural abnormalities in COVID-19 recovery.
These findings suggest a potential brain substrate for medium- to long-term symptoms after SARS-CoV-2 infection.