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Neurovascular responses to neuronal activity during sensory development
Lukas Konecny1, Rafid Quadir1, Abel Ninan1
1Department of Biology, City College, The City University of New York, New York, NY, United States.
Frontiers in Cellular Neuroscience
|November 28, 2022
Summary
Neuronal activity in newborn rodents causes intermittent hypoxia, promoting angiogenic factor production. This process is crucial for understanding brain development and responses to oxygen shortage.
Area of Science:
- Neuroscience
- Developmental Biology
- Physiology
Background:
- Intercellular communication in sensory regions is key to understanding newborn brain responses to oxygen deprivation.
- Neuronal activity influences sensory maturation during specific postnatal periods.
Purpose of the Study:
- To explore the hypothesis that neuronal activity drives angiogenic factor production via intermittent hypoxia.
- To examine the implications of this hypothesis in neonatal rodent models.
Main Methods:
- This perspective article reviews existing research and theoretical implications.
- Focuses on the interplay between neuronal activity, hypoxia, and angiogenesis.
Main Results:
- Neuronal activity can lead to local tissue hypoxic events during early postnatal development.
- This suggests neuronal oxygen consumption precedes angiogenic factor production.
Conclusions:
- Spontaneous sensory neuron activity may generate intermittent hypoxia in neonates.
- Intermittent hypoxia could induce hypoxia-inducible transcription factors (HIFs).
- Activity-dependent angiogenic factor production may play a role in pathological oxygen contexts.
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