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Updated: Aug 19, 2025

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Published on: April 13, 2015
The effect of neoadjuvant chemotherapy on the tumor immune microenvironment in gastrointestinal tumors
Yujie Wang1, Peng Gao2, Zhibin Hao1
1Department of Oncology, Changhai Hospital, Naval Military Medical University, Shanghai, China.
Abstract:
In recent years, numerous studies have demonstrated that the tumor immune microenvironment (TIME) is capable of regulating the growth of tumors, and tumor-infiltrating immune cells in the TIME can affect the prognosis and treatment responses of patients. Consequently, therapies targeting these immune cells have emerged as important antitumor treatments. As a crucial componet of the perioperative treatment of malignant tumors, neoadjuvant chemotherapy (NACT) can improve the surgical resection rate and prognosis of patients and is a suitable clinical model to evaluate the effect of chemotherapy on the TIME. To provide a rationale for developing valid combinational therapies, this review summarizes the impact of NACT on the TIME, the relationship between tumor-infiltrating immune cells and treatment responses of patients, and the prognostic value of these infiltrating immune cells.
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