Related Experiment Video

Updated: Aug 19, 2025

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

2.8K

Tangled relationship between insulin resistance and microalbuminuria in children with obesity

Alberto Maria Colasante1, Mario Bartiromo1, Michele Nardolillo1

  • 1Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy.

World Journal of Clinical Pediatrics
|November 28, 2022
PubMed

Insights

Childhood obesity is linked to kidney dysfunction, indicated by microalbuminuria (MA). This study explores the prevalence and connection between MA and insulin resistance (IR) in obese children, highlighting early kidney damage risks.

Area of Science:

  • Pediatrics
  • Nephrology
  • Endocrinology

Background:

  • Childhood obesity is a complex disease with significant cardiometabolic risks, including fatty liver, type 2 diabetes, metabolic syndrome, and cardiovascular disease.
  • Insulin resistance (IR) is a primary pathogenic factor driving these obesity-related complications.
  • Microalbuminuria (MA) is emerging as an early marker of kidney dysfunction and is potentially linked to cardiometabolic factors in children with obesity.

Purpose of the Study:

  • To investigate the prevalence of pediatric microalbuminuria (MA).
  • To review the current understanding of MA in children with obesity.
  • To examine the association between insulin resistance (IR) and MA in pediatric obesity.

Main Methods:

  • Literature review and synthesis of existing data on pediatric MA.
  • Analysis of studies correlating MA with obesity and cardiometabolic risk factors in children.
  • Exploration of pathophysiological mechanisms linking IR and renal hemodynamics in pediatric obesity.

Main Results:

  • Data on the prevalence of MA in the general pediatric population is presented.
  • The current state of knowledge regarding MA in the context of childhood obesity is summarized.
  • Evidence supporting a link between IR and MA in obese children is discussed, emphasizing the role of insulin in renal function.

Conclusions:

  • MA is a relevant indicator of early kidney damage in children with obesity.
  • The association between IR and MA in pediatric obesity warrants further investigation due to its clinical and prognostic implications.
  • Increased scientific attention is needed for evaluating early kidney damage in obese children, particularly concerning the IR-MA relationship.

Keywords:
ChildrenInsulin resistanceKidney damageMicroalbuminuriaObesity

More Related Videos

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion08:22

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion

Published on: March 20, 2017

8.8K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.2K

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
226
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.4K
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
579
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
647
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.9K