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Updated: Jul 25, 2026
14:23
Optical Recording of Electrical Activity in Guinea-pig Enteric Networks using Voltage-sensitive Dyes
Published on: December 4, 2009
Acid secretion by guinea-pig isolated stomach.
The Journal of Physiology
|February 1, 1976
Summary
Theophylline and histamine stimulate stomach acid secretion in guinea pigs. Theophylline potentiates histamine
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- The study investigates agents that stimulate gastric acid secretion.
- Understanding these mechanisms is crucial for treating acid-related disorders.
Purpose of the Study:
- To compare the effects of histamine, theophylline, and their derivatives on hydrochloric acid (HCl) secretion in an isolated guinea-pig stomach.
- To determine the dose-response relationships and potential synergistic effects of these secretagogues.
Main Methods:
- Utilized an isolated guinea-pig stomach preparation.
- Administered histamine acid phosphate, theophylline hydrate, Nalpha-MeH, Nalpha-Me2H, 5-MeH, and pentagastrin at varying concentrations.
- Measured and analyzed HCl secretion stimulated by these agents.
Main Results:
- Both histamine and theophylline dose-dependently stimulated HCl secretion, with theophylline showing a linear dose-response.
- Theophylline enhanced secretion during maximal histamine response, but histamine did not further increase secretion during maximal theophylline response.
- Nalpha-MeH was found to be a more potent secretagogue than histamine.
- Pentagastrin showed inconsistent and often transitory effects on HCl secretion.
Conclusions:
- Theophylline and histamine act as potent stimulators of gastric acid secretion.
- Theophylline may potentiate histamine-induced secretion, suggesting complex interactions in regulating HCl release.
- Nalpha-MeH represents a more effective agent for stimulating gastric acid secretion compared to histamine.
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