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Association between remnant cholesterol and arterial stiffness in a Chinese community-based population: A

Jiahui Liu1, Fangfang Fan1, Bo Liu1

  • 1Department of Cardiology, Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China.

Frontiers in Cardiovascular Medicine
|November 28, 2022
PubMed

Insights

Remnant cholesterol (RC) and triglycerides (TG) are significantly associated with arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV). These lipid markers show stronger links to arterial stiffness than other lipid indices in a Chinese population.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Vascular Biology

Background:

  • Arterial stiffness, a predictor of cardiovascular disease, is often assessed using brachial-ankle pulse wave velocity (baPWV).
  • Remnant cholesterol (RC) is an established independent risk factor for cardiovascular disease.
  • The relationship between RC and arterial stiffness (baPWV) remains underexplored.

Purpose of the Study:

  • To investigate the association between remnant cholesterol (RC) and brachial-ankle pulse wave velocity (baPWV) in a Chinese community-based population.
  • To determine if RC is an independent predictor of arterial stiffness.

Main Methods:

  • A cross-sectional study involving 8,028 Chinese adults aged ≥40 years.
  • Brachial-ankle pulse wave velocity (baPWV) was measured using a standard protocol.
  • Remnant cholesterol (RC) was calculated, and multivariate logistic regression analyses were performed to assess associations with baPWV, adjusting for other lipid parameters.

Main Results:

  • Both RC and triglycerides (TG) were positively and independently associated with baPWV.
  • Higher lipid profile quartiles, particularly the fourth, were linked to increased baPWV.
  • When analyzed together, only RC and TG concentrations remained significantly associated with baPWV, indicating a stronger link than other lipid indices.

Conclusions:

  • Lipid profiles, specifically remnant cholesterol (RC) and triglycerides (TG), are independently associated with arterial stiffness (baPWV).
  • RC and TG concentrations demonstrate a stronger association with arterial stiffness compared to other lipid indices in this Chinese population.
Abstract

Keywords:
arterial stiffnessbrachial-ankle pulse wave velocitycross-sectional studylipidsremnant cholesterol

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