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Systemic inflammation and risk of multiple sclerosis - A presymptomatic case-control study
Viktor Grut1, Martin Biström1, Jonatan Salzer1
1Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden.
Multiple Sclerosis Journal - Experimental, Translational and Clinical
|November 28, 2022
Summary
High-sensitivity C-reactive protein (hs-CRP) levels in young individuals were not associated with a reduced risk of developing multiple sclerosis (MS). This study found no link between hs-CRP and MS development.
Area of Science:
- Neuroimmunology
- Inflammation Biomarkers
Background:
- C-reactive protein (CRP) is a key indicator of systemic inflammation.
- Previous research suggested elevated CRP levels in young individuals might lower multiple sclerosis (MS) risk.
Purpose of the Study:
- To investigate the association between C-reactive protein (CRP) levels and the risk of developing multiple sclerosis (MS).
Main Methods:
- High-sensitive immunoassay measured CRP levels in biobank samples.
- Study included 837 individuals who developed MS and 984 matched controls.
- Conditional logistic regression analyzed MS risk based on z-scored CRP values.
Main Results:
- No statistically significant association was found between CRP levels and the risk of developing MS.
- CRP levels did not appear to be a predictive factor for MS development in the studied cohort.
Conclusions:
- The study concludes that CRP levels are not associated with the risk of MS development.
- Findings do not support the hypothesis that increased CRP levels in youth decrease MS risk.
