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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

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Correlations between gastrointestinal and oral microbiota in children with cerebral palsy and epilepsy

Congfu Huang1, Chunuo Chu2, Yuanping Peng3

  • 1Department of Pediatrics, Longgang District Maternity & Child Healthcare Hospital, Shenzhen, China.

Frontiers in Pediatrics
|November 28, 2022
PubMed

Insights

Children with cerebral palsy and epilepsy (CPE) show altered oral and gut microbiota. These microbial changes are linked to increased risks of periodontitis, caries, and malnutrition, highlighting the gut-oral microbiota connection.

Area of Science:

  • Microbiology
  • Human Health
  • Pediatrics

Background:

  • Cerebral palsy and epilepsy (CPE) are complex neurological conditions.
  • The interplay between oral microbiota (OM) and gut microbiota (GM) is increasingly recognized.
  • Understanding microbial dysbiosis in CPE is crucial for potential therapeutic interventions.

Purpose of the Study:

  • To investigate the correlation between oral and gut microbiota in children with CPE.
  • To identify specific microbial alterations in the oral cavity and gut of CPE children.
  • To explore the potential clinical implications of these microbial changes.

Main Methods:

  • 16S rRNA gene sequencing was used to analyze oral plaque and stool samples from 27 children with CPE.
  • Taxonomical annotation was performed to identify bacterial genera and their abundance.
  • Comparative analysis was conducted between CPE children and healthy controls.

Main Results:

  • CPE children exhibited significantly lower levels of Firmicutes and Bacteroides, and higher Actinomycetes in oral microbiota compared to healthy children.
  • Key oral genera in CPE included Prevotella, Fusobacterium, and Neisseria, potentially linked to caries, periodontitis, and malnutrition.
  • Gut microbiota in CPE children showed Bifidobacterium, Bacteroides, and Prevotella as dominant genera, possibly contributing to chronic inflammation and malnutrition.
  • Significant correlations were observed between oral and gut microbiota composition in CPE children.
  • Distinct microbial profiles were noted in both oral and gut environments of CPE children compared to healthy individuals.

Conclusions:

  • Dysbiosis in oral microbiota can translocate to the gut, inducing gut microbiota dysbiosis in children with CPE.
  • The findings suggest a consistent pattern of microbial alterations between the oral cavity and the gut in CPE.
  • Altered oral and gut microbial structures in CPE may contribute to the development of clinical conditions like periodontitis, caries, and malnutrition.

Keywords:
cerebral palsyepilepsygut microbiotamalnutritionoral microbiota

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