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Next-Generation Probiotics: Microflora Intervention to Human Diseases.

Huanchang Zhang1, Yunfeng Duan2, Feng Cai2

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Next-generation probiotics (NGPs) offer improved safety and targeted treatments. This review highlights key NGPs like Akkermansia muciniphila and Faecalibacterium prausnitzii for their therapeutic potential in human health.

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Area of Science:

  • Microbiology
  • Human Health
  • Gastroenterology

Background:

  • Advancements in sequencing and microbial culture have led to the discovery of novel microorganisms.
  • Emerging beneficial microorganisms are being developed as next-generation probiotics (NGPs).
  • Current NGP development focuses on safety, personalized medicine, and understanding microbial community interactions.

Purpose of the Study:

  • To review the progress in next-generation probiotics (NGPs) and their impact on human health.
  • To identify the limitations of traditional probiotics.
  • To summarize the functions and therapeutic potential of specific NGPs, including Akkermansia muciniphila, Faecalibacterium prausnitzii, Bacteroides fragilis, Eubacterium hallii, and Roseburia spp.

Main Methods:

  • Literature review of recent studies on NGPs and human health.
  • Analysis of the characteristics and functions of selected potential NGPs.
  • Evaluation of the role of these NGPs in disease treatment.

Main Results:

  • Key NGPs such as Akkermansia muciniphila and Faecalibacterium prausnitzii show significant promise.
  • These NGPs possess unique strengths for therapeutic interventions.
  • Understanding host-microbe interactions is crucial for NGP efficacy.

Conclusions:

  • NGPs represent a significant advancement over traditional probiotics.
  • Specific NGPs demonstrate potential for treating various diseases.
  • Further research is needed to fully harness the potential of NGPs for personalized health strategies.