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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
Recent advances in prevention, detection and treatment in prosthetic joint infections of bioactive materials
Hongbin Xie1,2,3, Yubo Liu1,2,3, Haoming An1,2,3
1Senior Department of Orthopedics, Fourth Medical Center of People's Liberation Army General Hospital, Beijing, China.
Abstract:
Prosthetic joint infection (PJI) is often considered as one of the most common but catastrophic complications after artificial joint replacement, which can lead to surgical failure, revision, amputation and even death. It has become a worldwide problem and brings great challenges to public health systems. A small amount of microbe attaches to the graft and forms a biofilm on its surface, which lead to the PJI. The current standard methods of treating PJI have limitations, but according to recent reports, bioactive materials have potential research value as a bioactive substance that can have a wide range of applications in the field of PJI. These include the addition of bioactive materials to bone cement, the use of antibacterial and anti-fouling materials for prosthetic coatings, the use of active materials such as bioactive glasses, protamine, hydrogels for prophylaxis and detection with PH sensors and fluorescent-labelled nanoparticles, and the use of antibiotic hydrogels and targeting delivery vehicles for therapeutic purposes. This review focus on prevention, detection and treatment in joint infections with bioactive materials and provide thoughts and ideas for their future applications.
Insights
Prosthetic joint infections (PJI) pose significant risks after artificial joint replacement. Bioactive materials show promise for preventing, detecting, and treating PJI, offering new therapeutic strategies.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Infectious Diseases
Background:
- Prosthetic joint infection (PJI) is a severe complication of artificial joint replacement, leading to adverse outcomes.
- Microbial biofilm formation on implants is a primary cause of PJI.
- Current PJI treatments have limitations, necessitating novel approaches.
Purpose of the Study:
- To review the applications of bioactive materials in the prevention, detection, and treatment of PJI.
- To explore the potential of bioactive substances in addressing challenges posed by PJI.
- To provide insights into future research directions for bioactive materials in PJI management.
Main Methods:
- Literature review focusing on bioactive materials for PJI.
- Analysis of applications in bone cement, prosthetic coatings, and drug delivery systems.
- Examination of materials for prophylaxis, detection (e.g., sensors, nanoparticles), and therapy (e.g., hydrogels).
Main Results:
- Bioactive materials offer diverse applications in PJI management.
- Examples include antibacterial coatings, bioactive glasses, and hydrogels for targeted delivery.
- PH sensors and fluorescent nanoparticles show potential for PJI detection.
Conclusions:
- Bioactive materials represent a promising frontier for PJI prevention, detection, and treatment.
- Further research is warranted to optimize their use in clinical settings.
- These materials could significantly improve outcomes for patients undergoing joint replacement.
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