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Small noncoding vault RNA2-1 disrupts gut epithelial barrier function via interaction with HuR.

Xiang-Xue Ma1, Lan Xiao1, Susan J Wen1

  • 1Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

EMBO Reports
|November 28, 2022
PubMed
Summary

Vault RNAs (vtRNAs) regulate the intestinal barrier by interacting with HuR. Elevated vtRNA2-1 impairs gut barrier function and protein translation, while its silencing enhances barrier integrity.

Keywords:
RNA-binding proteinsgut permeabilitymucosal defenseposttranscriptional regulationvault RNAs

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