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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

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Is mastocytic colitis a specific clinical-pathological entity?

Filippo Vernia¹, Tiziana Tatti², Stefano Necozione³

¹Gastroenterology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila. filippo.vernia1@gmail.com.

European Journal of Histochemistry : EJH

|November 28, 2022

Summary

This summary is machine-generated.

Increased intestinal mast cells (MC) correlate with higher evacuation rates in patients with chronic diarrhea. This suggests a potential new condition, "mastocytic colitis," characterized by elevated MC counts in the colonic mucosa.

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Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

Area of Science:

Gastroenterology
Immunology
Histopathology

Background:

Intestinal mast cells (MC) are implicated in colitis, but their role in chronic non-bloody diarrhea is understudied.
Previous research indicates increased MC counts in various colitis types, necessitating investigation into their role in other chronic diarrheal conditions.

Purpose of the Study:

To investigate the relationship between intestinal mast cell (MC) counts, degranulation, and symptom severity in patients experiencing chronic non-bloody diarrhea.
To explore the potential of MCs as a diagnostic marker for a specific subset of chronic diarrhea patients.

Main Methods:

Endoscopic biopsies were collected from 179 patients with chronic non-bloody loose stools after excluding common causes.
Biopsies were stained using hematoxylin and eosin and anti-CD117 c-kit antibodies for MC quantification and immunohistochemistry for MC degranulation assessment.
Patients were categorized into controls (normal histology), high MC counts (≥40 MC/HPF), and lymphocytic colitis (≥20 intraepithelial lymphocytes/HPF).

Main Results:

High MC counts (≥40 MC/HPF) were observed in 24 patients, and lymphocytic colitis (≥20 intraepithelial lymphocytes/HPF) in 23 patients.
Patients with high MC counts showed significantly higher evacuation rates compared to controls (p=0.025).
Mast cell degranulation was not significantly associated with evacuation rates, abdominal pain, or bloating.

Conclusions:

Elevated colonic mucosal mast cell counts are associated with increased evacuation rates in patients with chronic non-bloody diarrhea, suggesting a potential new clinical-pathological entity: "mastocytic colitis."
Further prospective studies with larger cohorts and histological follow-up are required to validate "mastocytic colitis" as a distinct diagnosis.