Transition-metal-free radical difluorobenzylation/cyclization of unactivated alkenes: access to ArCF2-substituted
Jin-Wei Yuan1, Mei-Yue Zhang1, Yan Liu1
1School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China. yuanjinweigs@126.com.
Abstract:
A mild and efficient transition-metal-free radical difluorobenzylation/cyclization of unactivated alkenes toward the synthesis of difluorobenzylated polycyclic quinazolinone derivatives with easily accessible α,α-difluoroarylacetic acids has been developed. This transformation has the advantages of wide functional group compatibility, a broad substrate scope, and operational simplicity. This methodology provided a highly attractive access to pharmaceutically valuable ArCF2-containing polycyclic quinazolinones.
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Radical Chain-Growth Polymerization: Overview
Radical Substitution: Allylic Chlorination
Radical Substitution: Halogenation of Alkanes and Alkyl Substituents
In the initiation step of the reaction, the chlorine molecule undergoes homolytic cleavage in the presence of light or heat, forming two highly reactive chlorine radicals. Propagation occurs in two...
Electrophilic Aromatic Substitution: Friedel–Crafts Acylation of Benzene
Electrophilic Aromatic Substitution: Friedel–Crafts Alkylation of Benzene


