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[Pathogenetic approaches to the treatment of sleep disorders in comorbid patients]

M V Putilina1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|November 28, 2022
PubMed

Insights

Insomnia exacerbates cardiovascular disease through inflammation and neurodegeneration. Peptide preparations like Cortexin show promise for treating sleep disorders and breaking this harmful cycle.

Area of Science:

  • Neuroscience
  • Cardiology
  • Pharmacology

Context:

  • Cardiovascular disease (CVD) incidence is rising, linked to sleep disorders like insomnia.
  • Insomnia initiates a detrimental cycle involving inflammation, hypothalamic-pituitary-adrenal axis disruption, neurodegeneration, and cognitive decline.

Purpose:

  • To explore the role of peptide preparations in managing sleep disorders and associated CVD risks.
  • To evaluate Cortexin as a potential pathogenetic therapy for sleep disorders.

Summary:

  • Peptide preparations offer a unique therapeutic approach by interacting with specific receptors to stimulate brain factors.
  • Cortexin, a Russian peptide with extensive research, demonstrates potential for treating sleep disorders.
  • Unlike other drugs, peptides can form new conformations with endogenous peptides, avoiding adverse effects and interactions.

Impact:

  • This research highlights a novel therapeutic strategy for sleep disorders, potentially mitigating associated cardiovascular risks.
  • Cortexin may offer a safe and effective treatment option for patients suffering from sleep disorders and related conditions.

Keywords:
Cortexincomorbid patientsinflammationinsomniapeptide drugssleep disorders

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