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Updated: Aug 19, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Gem-Difluoroallylation of Aryl Sulfonium Salts
Yue Zhao1, Claire Empel1, Wenjing Liang2
1Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Abstract:
The unprecedented photochemical late-stage defluorinative gem-difluoroallylation of aryl sulfonium salts, which are formed site-selectively by direct C(sp2)─H functionalization, is herein disclosed. This method is distinguished by its mild reaction conditions, wide scope, and excellent site-selectivity. As showcase examples, a Flurbiprofen and Pyriproxyfen derivatives could be late stage C(sp2)─H gem-difluoroallylated with high yields. Experimental and computational investigations were conducted.
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