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Updated: Aug 19, 2025

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation

Published on: March 17, 2023

Splitting the anterior mitral leaflet impairs left ventricular function in an ovine model.

Laurencie Brunel¹, Zoe A Williams², Konstantin Yastrebov³

¹Veterinary Specialists of Sydney, Miranda, NSW, Australia.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery

|November 28, 2022

Summary

Splitting the anterior mitral leaflet in sheep significantly reduced left ventricular function. Shortening the annulopapillary distance after leaflet splitting did not further impair cardiac performance.

Keywords:

Mitral valve Mitral valve replacement Valvular-ventricular interactions Left ventricular function

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Area of Science:

Cardiovascular Surgery
Cardiac Physiology
Surgical Techniques

Background:

Mitral valve replacement often involves anterior mitral leaflet resection or modification.
Anterior leaflet splitting is a less disruptive approach.
Reattaching the modified leaflet to the annulus shortens the annulopapillary distance.

Purpose of the Study:

To quantify the acute effects of anterior mitral leaflet splitting and annulopapillary distance shortening on left ventricular function.
To assess the impact of these modifications in an ovine model.

Main Methods:

Six adult sheep underwent anterior leaflet splitting and annulopapillary distance reduction using exteriorized wires and snares.
A mechanical mitral prosthesis was used to ensure valve competence during manipulations.
Left ventricular function was measured before and after each intervention.

Main Results:

Anterior leaflet splitting significantly decreased stroke volume, cardiac output, and left ventricular pressures.
Shortening the annulopapillary distance led to substantial reductions in contractility and systolic function.
Combined interventions did not result in further significant impairment.

Conclusions:

Anterior mitral leaflet splitting acutely impairs left ventricular contractility and hemodynamics.
Shortening the annulopapillary distance post-leaflet splitting does not exacerbate the functional decline.