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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
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Development of the Lymphatic System01:15

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Related Experiment Video

Updated: Aug 19, 2025

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
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Biliary atresia & choledochal malformation--Embryological and anatomical considerations.

Ancuta Muntean1, Mark Davenport1

  • 1Deptartment of Paediatric Surgery, Kings College Hospital, London.

Seminars in Pediatric Surgery
|November 28, 2022
PubMed
Summary
This summary is machine-generated.

Biliary atresia and choledochal malformations originate prenatally, but their exact causes remain unclear. Understanding early bile duct development may unlock insights into these pediatric liver diseases.

Keywords:
Biliary atresiaBiliary atresia splenic malformation syndromeBiliary ductal plateEmbryologyExtrahepatic ductIntrahepatic ducts

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Isolation of Neonatal Extrahepatic Cholangiocytes
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Area of Science:

  • Pediatric Hepatology
  • Developmental Biology
  • Gastroenterology

Background:

  • Biliary atresia (BA) and choledochal malformations (CM) are significant pediatric biliary diseases with prenatal origins.
  • The precise etiological mechanisms underlying BA and CM remain largely unknown.
  • Bile duct development involves complex embryonic processes, offering potential insights into disease pathogenesis.

Purpose of the Study:

  • To review the developmental origins of biliary pathologies in pediatric practice.
  • To explore the embryonic development of the biliary system in relation to BA and CM.
  • To highlight the current gaps in understanding the etiology of these conditions.

Main Methods:

  • Review of existing literature on embryonic bile duct development.
  • Analysis of developmental timing and cellular origins of biliary structures.
  • Correlation of developmental defects with known biliary pathologies.

Main Results:

  • The extrahepatic bile duct forms from foregut derivatives between 3-4 weeks gestation.
  • Intrahepatic bile ducts develop later (around 7-8 weeks) from the ductal plate.
  • Developmental defects in these processes are implicated in BA (especially Biliary Atresia Splenic Malformation syndrome) and cystic CM.

Conclusions:

  • While BA and CM have prenatal origins, their exact causes are elusive.
  • Understanding normal bile duct embryogenesis is crucial for elucidating the pathogenesis of BA and CM.
  • Further research into developmental anomalies is needed to clarify the etiology of these pediatric liver diseases.