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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Circular RNAs and tuberculosis infection.

Zahra Hemati1, Foroogh Neamati2, Mansoor Khaledi3

  • 1Department of Pathobiology, School of Veterinary Medicine, ShahreKord University, ShahreKord, Iran.

International Journal of Biological Macromolecules
|November 28, 2022
PubMed
Summary

Tuberculosis diagnosis can be improved using circulating plasma RNAs, specifically circular RNAs (circRNAs). These stable biomarkers offer a promising, non-sputum-based approach for rapid and cost-effective detection of Mycobacterium tuberculosis infection.

Keywords:
BiomarkerCircRNAsCircular RNAsMycobacterium tuberculosisNon-coding RNATuberculosis infection

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Infectious Diseases

Background:

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a significant global health challenge.
  • Current diagnostic and curative markers for TB are lacking, hindering effective disease management.
  • Rapid, non-sputum-based diagnostic methods are needed for primary care settings.

Purpose of the Study:

  • To review the role of circulating plasma RNAs in tuberculosis pathogenesis.
  • To evaluate circulating RNAs, particularly circular RNAs (circRNAs), as potential biomarkers for TB diagnosis.
  • To explore novel diagnostic strategies for tuberculosis.

Main Methods:

  • Literature review of studies on circulating RNAs and tuberculosis.
  • Analysis of circRNA characteristics, including stability and tissue specificity.
  • Investigation of circRNAs in serum as diagnostic indicators.

Main Results:

  • circRNAs are endogenous, stable, and abundant in the cytoplasm with tissue-specific expression.
  • circRNAs are detectable in serum, suggesting their potential as non-invasive biomarkers.
  • The unique structure of circRNAs confers resistance to degradation by nucleases.

Conclusions:

  • circulating plasma RNAs, especially circRNAs, show promise as novel biomarkers for tuberculosis diagnosis.
  • These biomarkers could facilitate rapid, cost-effective, and non-sputum-based TB detection.
  • Further research into circRNAs may lead to improved TB management strategies.