Zebrafish (Danio rerio): A newcomer with great promise in behavioral neuroscience

Behavioral neuroscience is an interdisciplinary field aimed at understanding the neurobiology of behavior. Numerous investigators turn to animals to model and understand the mechanisms underlying vertebrate brain function including human brain disorders, species that share evolutionary history with us. The zebrafish is a relatively new study species for such purposes. However, as this review attempts to demonstrate, it will likely have a good future in behavioral neuroscience. It is a simple vertebrate that is small and cheap to keep and study in the laboratory. Yet, it is similar enough to our own species, thus, we are able to use it for both translational as well as basic research. In this invited review, I will discuss its advantages and some of its disadvantages, the reasons and counterarguments why it should or should not be employed in research. I will focus on its utility in behavioral neuroscience, and will also provide a brief historical account of the evolution between zebrafish research and the science represented by the International Behavioral Neuroscience Society.