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Dementia Prevention in Clinical Practice.
Kellyann Niotis1, Kiarra Akiyoshi1, Caroline Carlton1
1Department of Neurology, Weill Cornell Medicine and New York - Presbyterian, New York, New York.
Seminars in Neurology
|November 28, 2022
Summary
Dementia affects millions globally. Personalized prevention strategies, focusing on modifiable risk factors identified through comprehensive risk stratification, offer a promising approach to delay or prevent Alzheimer's disease.
Area of Science:
- Neurology
- Public Health
- Gerontology
Background:
- Over 55 million people live with dementia worldwide, projected to reach 131 million by 2050.
- This escalating public health crisis necessitates a shift towards primary and secondary prevention strategies.
- Alzheimer's disease (AD), the most common dementia, has an estimated 40% of cases potentially preventable or delayable.
Approach:
- Focusing on personalized, multidomain interventions targeting modifiable risk factors is more effective than a "one-size-fits-all" approach.
- Early intervention in at-risk individuals using individualized strategies is supported by evolving evidence.
- Comprehensive risk stratification, incorporating clinical history, biomarkers, and genetics, informs precision medicine for dementia.
Key Points:
- Risk stratification is crucial for differentiating dementia subtypes and identifying intervention targets.
- Personalized interventions address modifiable risk factors, enhancing prevention efficacy.
- Precision medicine principles guide comprehensive risk assessment for tailored dementia prevention.
Conclusions:
- A clinical approach to dementia risk stratification and evidence-based prevention is essential.
- Individualized interventions based on risk assessment are key to managing the dementia epidemic.
- Focusing on modifiable risk factors offers a viable strategy to delay or prevent Alzheimer's disease.
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