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The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases
Yang Sun1, Yue Li2, Jiting Zhang3
1Department of Orthopedics, The First Hospital of Jilin University, Changchun, Jilin, China.
Abstract:
Psoriasis is more common in patients with inflammatory bowel disease (IBD) than in the general population. Similarly, patients with psoriasis or psoriatic arthritis (PsA) have a higher incidence of IBD. However, whether this association is causal remains unknown. Therefore, we used a two-sample bidirectional Mendelian randomization (MR) analysis to identify this relationship. According to MR analysis, psoriasis and PsA causally increased the odds of developing Crohn's disease (OR = 1.350 (1.066-1.709) P = 0.013; OR = 1.319 (1.166-1.492) P < 0.001). In contrast, MR estimates gave little support to a possible causal effect of psoriasis, PsA, on ulcerative colitis (OR = 1.101 (0.905-1.340) P = 0.335; OR = 1.007 (0.941-1.078) P = 0.831). Similarly, the reverse analysis suggested the Crohn's disease causally increased the odds of psoriasis and PsA (OR = 1.425 (1.174-1.731) P < 0.001; OR = 1.448 (1.156-1.182) P = 0.001), whereas there are no causal association between ulcerative colitis and psoriasis, PsA (OR = 1.192 (0.921-1.542) P = 0.182; OR = 1.166 (0.818-1.664) P = 0.396). In summary, our MR analysis strengthens the evidence for the bidirectional dual causality between psoriasis (including PsA) and Crohn's disease.
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