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Assessment of cognitive function and its predictors in patients with multiple sclerosis: a case-control study
Dila Basci1,2, Zeliha Tulek3
1Institute of Graduate Studies, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Summary
Cognitive dysfunction is prevalent in patients with multiple sclerosis (MS). Education, depression, and fatigue significantly impact cognitive performance in individuals with MS, highlighting areas for potential intervention.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Cognitive dysfunction is increasingly recognized in patients with multiple sclerosis (PwMS).
- This study investigates cognitive function and its associated factors in PwMS.
Purpose of the Study:
- To assess cognitive function in patients with multiple sclerosis (PwMS) using the Addenbrooke Cognitive Assessment Battery (ACE-R).
- To identify determinants of cognitive dysfunction in PwMS.
Main Methods:
- A case-control study involving 60 PwMS and 60 matched healthy controls.
- Cognitive function assessed using ACE-R; subjective cognitive function, anxiety, depression, and fatigue evaluated via validated scales.
Main Results:
- PwMS demonstrated significantly lower scores across all ACE-R domains compared to controls.
- Memory and verbal fluency were the most affected domains, while visuospatial function was least affected.
- Education, depression, and fatigue were significant predictors of cognitive performance in multivariable analysis.
Conclusions:
- Cognitive functioning is impaired in PwMS, with specific domains affected.
- Identifying predictors like education, depression, and fatigue can guide interventions to improve cognitive outcomes.
- Practical cognitive assessments in outpatient settings are recommended for PwMS.
