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Related Experiment Video

Updated: Aug 19, 2025

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

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Devices for donor lung preservation.

Cora R Bisbee1, Curry Sherard, Jennie Kwon1

  • 1College of Medicine, Medical University of South Carolina, Charleston, SC, USA.

Expert Review of Medical Devices
|November 29, 2022
PubMed
Summary
This summary is machine-generated.

Lung transplant preservation is evolving. Novel ex vivo lung perfusion (EVLP) offers extended donor lung viability and assessment, overcoming limitations of static cold storage for end-stage lung disease treatment.

Keywords:
DCDECDEVLPLung transplantationTransMedics OCSXVIVOlung perfusionstatic cold storagetransplant devices

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Area of Science:

  • Pulmonary medicine and transplant surgery.
  • Organ preservation and bioengineering.

Background:

  • Lung transplantation is vital for end-stage lung disease but faces donor shortages.
  • Liberalized donor criteria expand the pool but require longer preservation.
  • Static cold storage is standard but has limitations in mitigating organ damage.

Approach:

  • Review of current and novel lung preservation strategies.
  • Evaluation of static cold storage versus ex vivo lung perfusion (EVLP) systems.
  • Analysis of critical components in EVLP: perfusate, solutions, temperature, and damage assessment.

Key Points:

  • Ex vivo lung perfusion (EVLP) systems (e.g., TransMedics OCS, XVIVO) extend preservation time.
  • EVLP allows for donor lung ventilation and viability assessment.
  • EVLP may optimize extended criteria donors and mitigate ischemic injury.

Conclusions:

  • EVLP offers advantages over static cold storage for lung graft management.
  • Despite higher costs, EVLP provides enhanced functional assessment and injury mitigation.
  • Technological advancements in EVLP are crucial for expanding lung transplant accessibility.