Introduction of soy-free plant-based pediatric formula in infants with FPIES: A case report

Background: Standard practice for management of food protein-induced enterocolitis syndrome (FPIES) frequently requires the use of hypoallergenic semi-elemental or elemental formulas. For some patients, there is poor tolerance of these formulas and no improvement of gastrointestinal symptoms. For others, especially those over 4 months of age, the introduction of these formulas is difficult due to their scientifically demonstrated poor palatability. Case presentation: This case report features an 18-month-old child diagnosed with FPIES at 4 months who failed to tolerate standard hypoallergenic semi-elemental and elemental formulas to supplement maternal breast milk feedings resulting in suboptimal growth. After failing to tolerate all standard options, the patient was introduced off-label to a plant-based pediatric formula, Else Toddler, at 6 months-of-age. Outcomes and implications: In this case, Else Toddler was tolerated as a source of supplemental nutrition without triggering FPIES symptoms. Recommendations: This case demonstrates the successful use of Else Toddler, a pediatric formula sourced from almond butter, buckwheat flour, and tapioca maltodextrin, as a possible alternative to the standard use of hydrolysate or elemental amino-acid formulas. It is free of some of the most common FPIES triggers - dairy, soy, rice, and pea proteins and there for a possible acceptable alternative approach to FPIES management.