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Updated: Aug 19, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Iron-catalysed reductive coupling for the synthesis of polyfluorinated compounds
Yu-Qiu Guan1,2, Tian-Zhang Wang2, Jia-Fan Qiao2
1Center for Molecular Science and Engineering, College of Sciences, Northeastern University, Shenyang 110819, China. chenzhangpei@mail.neu.edu.cn.
Abstract:
Herein we reported the use of Earth-abundant iron as the catalytic metal in the presence of Mn to induce difluorobromoacetates to form carbon radicals, which reacted with trifluoromethyl olefins followed by β-F elimination to generate the corresponding gem-difluoroolefins. The cross-electrophile coupling displayed excellent functional group tolerance and broad substrate scope under mild reductive conditions, affording a large number of polyfluorinated compounds, which could be further transformed to other valuable molecules.
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