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A review on the role of miR-210 in human disorders

Sheyda Khalilian1, Atefeh Bijanvand2, Hamid Abedinlou3

  • 1Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|November 29, 2022
PubMed

Insights

MicroRNA-210 (miR-210) is a key regulator in human disease, particularly cancer. This review comprehensively summarizes its significant role in various human disorders.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNA-210 (miR-210) is a significant miRNA involved in human disease pathophysiology.
  • Encoded by the MIR210 gene, its expression is notably upregulated under hypoxic conditions, classifying it as a major hypoxamir.
  • miR-210 dysregulation is observed in numerous cancer types, often correlating with poor clinical outcomes.

Purpose of the Study:

  • To provide a comprehensive review of microRNA-210's involvement in human disorders.
  • To highlight the role of miR-210 in the pathophysiology of various diseases, especially cancers.

Main Methods:

  • Literature review of studies investigating microRNA-210.
  • Analysis of miR-210 expression patterns in different human diseases.
  • Correlation of miR-210 dysregulation with clinical outcomes.

Main Results:

  • miR-210 expression is increased in hypoxic conditions and upregulated in most cancer types.
  • Exceptions to upregulation include bladder cancer, angiosarcoma, and glioblastoma.
  • Dysregulated miR-210 is linked to adverse clinical outcomes in colorectal carcinoma, gastric cancer, and others.

Conclusions:

  • MicroRNA-210 plays a critical role in the pathophysiology of numerous human disorders.
  • Understanding miR-210's function offers insights into disease mechanisms and potential therapeutic targets.
Keywords:
BiomarkersCancerMiR-210MicroRNAsNoncoding RNA

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