Related Experiment Video
Updated: Jul 28, 2026

09:25
Purification of Pathogen Vacuoles from Legionella-infected Phagocytes
Published on: June 19, 2012
12.6K
Why Hoffmann? His Chemistry
1Department of Chemistry, University of Richmond, 23173, Richmond, VA, USA.
Abstract:
Why was it that Roald Hoffmann was the perfect collaborator for R. B. Woodward for proposing the Principle of Conservation of Orbital Symmetry as the solution to the no-mechanism puzzle? This publication presents 17 "tools" that Hoffmann used extensively and effectively prior to the Woodward-Hoffmann collaboration that would he call upon reveal the mechanism of pericyclic reactions. In a sense, this is a biography of Hoffmann with a focus on his personal and professional skills as of May 5, 1964.

