Related Experiment Video

Updated: Aug 19, 2025

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.2K

Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications

Rachana D Shah1, Steven D Chernausek2, Laure El Ghormli3

  • 1Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

The Journal of Clinical Endocrinology and Metabolism
|November 29, 2022
PubMed

Insights

Maternal diabetes history negatively impacts glycemic control and increases risks for complications in youth with type 2 diabetes (T2D). These findings suggest potential in utero programming effects influencing long-term health outcomes.

Area of Science:

  • Endocrinology and Metabolism
  • Pediatric Health
  • Cardiometabolic Disease Research

Background:

  • Prenatal exposures like parental diabetes are known risk factors for cardiometabolic diseases.
  • Limited data exist on the impact of parental diabetes on disease progression in youth-onset type 2 diabetes (T2D).

Purpose of the Study:

  • To analyze the effects of parental diabetes history on glycemic outcomes, beta-cell function, and complications in a US cohort of youth-onset T2D.
  • To investigate the association between maternal and paternal diabetes and disease progression in adolescents with T2D.

Main Methods:

  • Analysis of data from 699 participants (aged 10-17 years) in the TODAY and TODAY2 studies, followed for up to 12 years.
  • Assessment of maternal and paternal diabetes history in relation to glycemic control (HbA1c), glomerular hyperfiltration, and heart rate variability.

Main Results:

  • Maternal diabetes, irrespective of timing (during or after pregnancy), was significantly associated with loss of glycemic control (HbA1c ≥ 8%).
  • Paternal diabetes showed no significant association with these outcomes.
  • Maternal diabetes was linked to increased risks of glomerular hyperfiltration and low heart rate variability over 12 years.

Conclusions:

  • Maternal diabetes is a significant factor associated with poorer glycemic control and adverse cardiometabolic complications in youth with T2D.
  • The findings suggest a potential role for in utero programming in the development of T2D complications.
  • Further research is warranted to elucidate the mechanisms behind maternal diabetes's influence on T2D progression in offspring.
Abstract

Keywords:
dysglycemiaheart rate variabilityhyperfiltrationmaternal diabetestype 2 diabetesyouth

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.9K
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.6K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.1K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
647
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.9K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.4K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
328