Related Experiment Video
Updated: Aug 19, 2025
10:44
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
13.3K
Ribociclib and palbociclib-induced erythema multiforme: a case report.
Eleni Vrana1, Stella Mylona2, Mattheos Bobos3
1"Euromedica" General Clinic, Oncology Department, 54645 Thessaloniki, Greece.
Oxford Medical Case Reports
|November 30, 2022
Summary
Severe skin reactions, like erythema multiforme (EM), can rarely occur with cyclin-dependent kinase 4/6 inhibitors (CKIs) such as ribociclib and palbociclib. Prompt recognition and management of these rare dermatologic toxicities are crucial.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Cyclin-dependent kinase 4/6 inhibitors (CKIs) like ribociclib, palbociclib, and abemaciclib are approved for HR+, HER2- advanced or metastatic breast cancer.
- While generally well-tolerated, CKIs can rarely cause severe dermatological adverse events requiring prompt management.
More Related Videos
Related Concept Videos
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
591
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
591
01:21Barrett Esophagus-II: Clinical Manifestations and Management
253
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
253
01:14Changes in Skin Color: Clinical Perspectives
2.1K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.1K
02:34Inhibition of Cdk Activity
4.9K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K