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Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
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Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice

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A Patient With Myelin Oligodendrocyte Glycoprotein Positive Encephalitis With Ring Enhancing Lesions on Magnetic

Jamie Jacobs1, Priscilla Vu1, Antonio K Liu2,3

  • 1Internal Medicine, Adventist Health White Memorial, Los Angeles, USA.

Cureus
|November 30, 2022
PubMed

Insights

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis is rare, especially with unusual MRI findings. This case highlights MOG antibody positivity in a patient with COVID-19 exposure presenting with altered mental status and ring-enhancing brain lesions.

Area of Science:

  • Neurology
  • Immunology
  • Infectious Disease

Background:

  • Myelin oligodendrocyte glycoprotein (MOG) antibody is linked to various neurological conditions.
  • MOG antibody-associated encephalitis is infrequently reported, particularly with isolated presentations.
  • Typical MRI findings involve demyelination.

Observation:

  • A patient with COVID-19 exposure presented with altered mental status.
  • Cerebral MRI revealed multiple ring-enhancing lesions, mimicking metastatic disease.
  • The initial presentation and imaging findings obscured the diagnosis.

Findings:

  • MOG antibody testing confirmed the diagnosis.
  • This case demonstrates an unusual presentation of MOG antibody disease.
  • The patient's presentation was atypical for MOG antibody-associated encephalitis.

Implications:

  • This case expands the spectrum of MOG antibody disease presentations.
  • It underscores the importance of considering MOG antibody testing in encephalitis, even with atypical MRI findings.
  • Highlights the potential neuroinflammatory impact of viral infections like COVID-19.
Keywords:
autoimmune encephalitiscovidintravenous immunoglobulins (ivig)myelin-oligodendrocyte glycoprotein (mog)ring-enhancing brain lesion

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