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Graft and Patient Survival Rate among Iranian Pediatric Recipients of Kidney Transplantation: A Systematic Review and

Ahmad Shajari1, Mohammad Moein Ashrafi2, Hamideh Shajari3

  • 1Ali-Ebne-Abitaleb School of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran.

Iranian Journal of Public Health
|November 30, 2022
PubMed

Insights

This systematic review and meta-analysis evaluated kidney transplant survival rates in Iranian children with end-stage renal disease (ESRD). Pediatric kidney transplant survival rates at 1, 5, and 10 years were 91%, 81%, and 70% respectively.

Area of Science:

  • Pediatric Nephrology
  • Transplantation Immunology
  • Public Health

Background:

  • End-Stage Renal Disease (ESRD) necessitates long-term alternative therapies, particularly in pediatric patients.
  • Kidney transplantation is a critical treatment for children with ESRD, requiring evaluation of long-term outcomes.
  • Assessing graft and patient survival rates is crucial for optimizing pediatric kidney transplant care.

Purpose of the Study:

  • To evaluate graft and patient survival rates in Iranian pediatric kidney transplant recipients.
  • To provide a comprehensive evidence base for planning and policy-making in pediatric kidney transplantation.
  • To estimate survival rates for children undergoing kidney transplantation in Iran.

Main Methods:

  • A systematic review and meta-analysis of studies on pediatric kidney transplantation in Iran.
  • Searched national and international databases (1985-Nov 2019) including PubMed, Scopus, Web of Science, Cochrane.
  • Analyzed data from 10 studies involving 2673 pediatric recipients using random-effects modeling and meta-regression.

Main Results:

  • The study included 2673 pediatric kidney transplant recipients with an average age of 13.71 years.
  • Estimated survival rates for kidney transplantation were 91% at 1 year, 88% at 3 years, 81% at 5 years, and 70% at 10 years.
  • Meta-regression explored factors influencing heterogeneity in survival rates across different cities.

Conclusions:

  • The findings provide documented evidence on pediatric kidney transplant survival in Iran.
  • Results can inform health policy, treatment program evaluation, and intervention planning for pediatric kidney transplantation.
  • The study offers valuable insights for improving outcomes and resource allocation in pediatric renal replacement therapy.
Abstract

Keywords:
End stage renal diseaseGraft survivalKidney transplantationMeta-analysisPatient survival

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