Related Experiment Video

Updated: Aug 19, 2025

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

486

Diabetic and stress-induced hyperglycemia in spontaneous intracerebral hemorrhage: A multicenter prospective cohort

Shaoli Chen1, Yan Wan1, Hongxiu Guo1

  • 1Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

CNS Neuroscience & Therapeutics
|November 30, 2022
PubMed

Insights

Stress-induced hyperglycemia (SIH) in patients with intracerebral hemorrhage (ICH) is linked to increased risks of pulmonary infection and mortality. This finding highlights SIH as a critical factor impacting outcomes after ICH.

Area of Science:

  • Neurology
  • Endocrinology
  • Critical Care Medicine

Background:

  • Admission hyperglycemia is frequent in spontaneous intracerebral hemorrhage (ICH).
  • Causes include pre-existing diabetes mellitus (DM) and stress-induced hyperglycemia (SIH).
  • Limited research exists on the link between SIH and ICH outcomes.

Purpose of the Study:

  • To determine if SIH or pre-existing DM causes admission hyperglycemia in ICH patients.
  • To investigate the association between hyperglycemia subtypes and ICH outcomes.

Main Methods:

  • Analysis of admission glycosylated hemoglobin (HbA1c), glucose levels, and comorbidity data from the CHEERY study.
  • Classification of patients into nondiabetic normoglycemia, diabetic normoglycemia, diabetic hyperglycemia, and SIH groups.
  • Use of modified Poisson regression models to assess ICH outcomes.

Main Results:

  • 1372 patients were analyzed; 388 had admission hyperglycemia (239 with DH, 149 with SIH).
  • SIH was associated with increased risk of pulmonary infection (RR: 1.477).
  • SIH correlated with higher 30-day (RR: 1.068) and 90-day mortality (RR: 1.060) after ICH.

Conclusions:

  • Admission hyperglycemia is common post-ICH.
  • SIH is a significant predictor of pulmonary infection and mortality risk following ICH.
Abstract

Keywords:
diabetes mellitushyperglycemiaintracerebral hemorrhagestress-induced hyperglycemia; prognosis

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