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Related Concept Videos

Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Related Experiment Video

Updated: Aug 19, 2025

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
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Association between prediabetes and cognitive function in Parkinson's disease.

Joah Park1, Seohee Choi2, Ryul Kim2

  • 1Department of Medicine, Inha University College of Medicine, Incheon, Korea.

Brain and Behavior
|November 30, 2022
PubMed
Summary

Prediabetes is linked to cognitive impairment in Parkinson's disease (PD) patients, similar to diabetes. This finding suggests prediabetes management may be crucial for preserving cognitive function in individuals with PD.

Keywords:
Parkinson's diseasecognitiondiabetesprediabetes

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Area of Science:

  • Neurology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Cognitive impairment is a common non-motor symptom in Parkinson's disease (PD).
  • The relationship between prediabetes and cognitive function in PD patients is not well understood.
  • Early detection and management of metabolic conditions like prediabetes may be important for PD progression.

Purpose of the Study:

  • To investigate the association between prediabetes and cognitive function in Parkinson's disease patients.
  • To compare cognitive performance across groups with diabetes, prediabetes, and no diabetes.

Main Methods:

  • A cross-sectional study involving 262 Parkinson's disease patients.
  • Patients were categorized into diabetes (HbA1c ≥6.5%), prediabetes (5.7%-6.4%), and diabetes-free (≤5.6%) groups.
  • Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) test.

Main Results:

  • Both diabetes and prediabetes groups exhibited significantly lower MoCA scores compared to the diabetes-free group, even after adjusting for confounders.
  • Higher glycated hemoglobin (HbA1c) levels correlated with lower MoCA scores in the combined prediabetes and diabetes-free cohort.
  • Diabetes status interacted significantly with age, but not PD duration, impacting cognitive function.

Conclusions:

  • Prediabetes, in addition to diabetes, may negatively impact cognitive function in Parkinson's disease.
  • Further prospective studies are needed to understand the long-term effects of prediabetes on cognitive decline in PD.
  • Managing prediabetes could be a potential strategy to support cognitive health in PD patients.