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Superimposed mosaicism in cutaneous sarcoidosis: A hypothesis

Rudolf Happle¹, Martin Wetzke²

¹Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.

American Journal of Medical Genetics. Part A

|November 30, 2022

Abstract:

Sarcoidosis is a chronic granulomatous disorder affecting the lungs, skin, and many other organs. Twin studies suggest that genetic factors account, to a large degree, for the etiology of the disorder. Hence, theoretically, we could postulate that the phenomenon of superimposed mosaicism in the form of a pronounced segmental involvement, overlaying the disseminated non-segmental lesions, should also occur in sarcoidosis. Indeed, one case suggesting superimposed mosaicism in cutaneous sarcoidosis was found in the literature and is reassessed here.

Keywords:

cutaneous sarcoidosis flag-like pattern polygenic disorder segmental manifestation superimposed mosaicism twin studies

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