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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Chronic viral hepatitis accelerates lung function decline in smokers.

Suh-Young Lee1, Sun-Sin Kim1,2, So-Hee Lee1,2

  • 1Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Clinical and Experimental Medicine
|November 30, 2022
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Chronic viral hepatitis (CVH) significantly accelerates lung function decline in smokers. This association is stronger in smokers with advanced liver fibrosis, suggesting non-invasive fibrosis assessment can predict pulmonary decline.

Keywords:
Chronic hepatitis BChronic hepatitis CForced expiratory volumeRespiratory function testsSmokingTrajectory

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Area of Science:

  • Hepatology
  • Pulmonology
  • Virology

Background:

  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) primarily affect the liver but can impact pulmonary health.
  • Chronic viral hepatitis (CVH) may be linked to accelerated lung function decline.

Purpose of the Study:

  • To investigate the association between chronic viral hepatitis (CVH) and the rate of lung function decline.
  • To assess if CVH impacts lung function in smokers and non-smokers separately.

Main Methods:

  • Utilized a health check-up database with repeated lung function measurements.
  • Defined cases as individuals positive for HBsAg or anti-HCV antibody, matched 1:1 with controls.
  • Conducted separate analyses for smokers and non-smokers, including cross-sectional and longitudinal assessments.

Main Results:

  • CVH was associated with significantly decreased lung function (FEV1 and FVC) in smokers compared to controls.
  • Smokers with CVH exhibited accelerated rates of FEV1 and FVC decline.
  • The association was more pronounced in smokers with intermediate-to-high risk of hepatic fibrosis (using Fibrosis-4 index).

Conclusions:

  • Chronic viral hepatitis is linked to reduced lung function and faster lung function decline in smokers.
  • Non-invasive hepatic fibrosis assessment may aid in predicting rapid lung function decline in smokers with CVH.