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Albumin level as an independent predictive factor for adverse outcomes in COVID-19 patients: a retrospective cohort

Congyi Xie1, Sijiao Wang2, Jian Zhou2

  • 1Department of Pulmonary Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China.

Journal of Infection in Developing Countries
|November 30, 2022
PubMed

Insights

Low albumin levels are linked to worse outcomes in COVID-19 patients. Albumin is an independent predictor of adverse events, with levels below 32.6 g/L showing a strong negative correlation with risk.

Area of Science:

  • Clinical Medicine
  • Infectious Diseases
  • Biochemistry

Background:

  • Limited research exists on the association between albumin (ALB) levels and clinical outcomes in coronavirus disease 2019 (COVID-19).
  • Understanding predictors of adverse outcomes is crucial for managing COVID-19 patients.

Purpose of the Study:

  • To investigate the relationship between serum albumin levels at admission and adverse clinical outcomes in COVID-19 patients.
  • To determine if albumin level is an independent predictor of adverse events in COVID-19.

Main Methods:

  • Retrospective cohort study of 199 COVID-19 patients.
  • Collected clinical characteristics and laboratory values at admission.
  • Utilized univariate/multivariate linear regression and generalized additive models (GAM) to analyze ALB and adverse outcomes.

Main Results:

  • A non-linear relationship was identified between ALB levels and adverse outcomes, with an inflection point at 32.6 g/L.
  • Below 32.6 g/L, ALB was negatively correlated with adverse outcomes; each 1 unit increase reduced risk by 79.6% (OR 0.204).
  • Above 32.6 g/L, the correlation was weaker (OR 0.908).

Conclusions:

  • The relationship between serum albumin and adverse outcomes in COVID-19 is non-linear.
  • Serum albumin level is an independent predictive factor for adverse outcomes in COVID-19 patients.
Abstract

Keywords:
COVID-19albuminoutcomepredictive factor

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