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Subtyping of Campylobacter jejuni ssp. doylei Isolates Using Mass Spectrometry-based PhyloProteomics MSPP
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Review on Cyclosporiasis Outbreaks and Potential Molecular Markers for Tracing Back Investigations

Junqiang Li1,2,3, Feifei Xu1, Md Robiul Karim4

  • 1College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

Foodborne Pathogens and Disease
|November 30, 2022
PubMed

Insights

Cyclosporiasis, caused by Cyclospora cayetanensis, is a growing global health concern. Identifying molecular markers is crucial for effective outbreak investigation and source tracking to control this emerging infectious disease.

Area of Science:

  • Infectious Diseases
  • Molecular Epidemiology
  • Public Health

Background:

  • Cyclosporiasis, caused by Cyclospora cayetanensis, is an emerging gastrointestinal illness with increasing global incidence.
  • The pathogen is associated with significant travel- and food-related outbreaks, posing a worldwide public health challenge.
  • Current molecular investigation tools for Cyclospora cayetanensis are limited, with only one FDA-approved platform available.

Approach:

  • This review examines major cyclosporiasis outbreaks globally.
  • It explores potential molecular markers and genotyping strategies for C. cayetanensis.
  • The focus is on enhancing molecular tools for tracing outbreak sources.

Key Points:

  • Current molecular investigation of cyclosporiasis outbreaks is limited, with only one FDA-approved platform available.
  • Genotyping based on polymorphic regions of C. cayetanensis genomes can differentiate outbreak clusters.
  • Effective epidemiological tools are crucial for source tracking and control, especially given the lack of a vaccine.

Conclusions:

  • Effective epidemiological investigation and source tracking are vital for controlling cyclosporiasis outbreaks.
  • Developing and implementing advanced molecular tools are essential for understanding and managing this emerging infectious disease.
  • Further global research promoting epidemiological studies on human cyclosporiasis is recommended to improve disease management.
Keywords:
cyclosporosismolecular markersoutbreakstracing back investigations

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