Related Experiment Video
Updated: Aug 19, 2025
13:08
Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
27.7K
Fanconi Syndrome Associated with Long-term Treatment with Zoledronate
Rinko Katsunuma1, Kensuke Mitsumoto1, Aya Mizumoto1
1Department of Nephrology, Nippon Life Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|November 30, 2022
Summary
Long-term bisphosphonate therapy for bone metastasis can cause kidney damage, leading to osteomalacia. Monitoring renal and bone health is crucial for patients receiving zoledronic acid treatment.
Area of Science:
- Oncology
- Nephrology
- Endocrinology
Background:
- Intravenous bisphosphonates, such as zoledronic acid, are standard treatments for preventing fractures in patients with bone metastasis.
- Renal damage is a potential adverse effect of bisphosphonate therapy, particularly with long-term use.
Observation:
- An 81-year-old woman with metastatic breast cancer developed Fanconi syndrome and osteomalacia after over 5 years of zoledronic acid treatment.
- The patient's bone markers normalized after discontinuing zoledronic acid, switching to denosumab, and initiating vitamin D and mineral supplementation.
Findings:
- This case highlights that chronic kidney damage induced by zoledronic acid can manifest as osteomalacia.
- The findings suggest a direct link between zoledronic acid-induced nephrotoxicity and the development of bone metabolic disorders.
Implications:
- Close monitoring of renal function and bone markers is essential for patients undergoing long-term intravenous bisphosphonate therapy.
- Alternative treatment strategies and supportive care should be considered in patients experiencing renal complications from bisphosphonates.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
60
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
60
01:29Bone Disorders
3.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.8K
01:11Renal Failure: Dose Adjustments
136
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
136
01:18Chronic Kidney Disease IV: Nursing Management
40
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
40