Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.8K
Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative study of three PCR-based copy number variant approaches, CFMSA, M-PCR, and MLPA, in 22q11.2 deletion syndrome.

Genetic testing and molecular biomarkers·2009
Same author

[Influence on electroacupuncture at "Qiangzhuang" acupoints for neuro-immune regulation of sub-acute aged rats].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2009
Same author

[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2009
Same author

[Treatment of nonunion of tibia with superficial peroneal vascular fascia pedicel tibiofibular periosteal flap].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·2009
Same author

[Expression, purification and activity analysis of BCG HSP70.].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2009
Same author

Comparison of diffusion-weighted with T2-weighted Imaging for detection of small hepatocellular carcinoma in cirrhosis: preliminary quantitative study at 3-T.

Academic radiology·2009

Related Experiment Video

Updated: Aug 19, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.6K

Association between mixed aldehydes and bone mineral density based on four statistical models.

Lanxin Gu1,2,3, Zhongyuan Wang4, Luwei Liu1,2,3

  • 1Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, 210029, China.

Environmental Science and Pollution Research International
|November 30, 2022
PubMed
Summary

Environmental aldehydes, particularly hexanaldehyde and propanaldehyde, are linked to reduced bone mineral density (BMD) in men, suggesting a need for stricter regulation to prevent osteoporosis.

Keywords:
AldehydeBKMRBMDJoint effectNHANES

More Related Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.3K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.5K

Related Experiment Videos

Last Updated: Aug 19, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.6K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.3K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.5K

Area of Science:

  • Environmental Health
  • Bone Metabolism
  • Toxicology

Background:

  • Aldehydes are environmental pollutants linked to oxidative stress, a key factor in osteoporosis development.
  • Understanding the impact of mixed aldehyde exposure on bone mineral density (BMD) is crucial for public health.
  • Previous research has not fully explored the combined effects of multiple aldehydes on osteoporosis risk.

Purpose of the Study:

  • To investigate the associations between exposure to a mixture of six aldehydes and BMD in men and women.
  • To identify specific aldehydes contributing to BMD reduction and explore potential non-linear relationships.
  • To provide insights into novel prevention and treatment strategies for osteoporosis.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014.
  • Applied advanced statistical models including quantile g-computation (qgcomp), Bayesian kernel machine regression (BKMR), generalized linear regression (GLM), and generalized additive model (GAM).
  • Analyzed mixed exposure of six aldehydes: benzaldehyde, butyraldehyde, heptanal, hexanal, isovaleraldehyde, and propionaldehyde in men, premenopausal women, and postmenopausal women.

Main Results:

  • Mixed aldehyde exposure was significantly associated with reduced BMD in men.
  • Hexanaldehyde and propanaldehyde showed the strongest negative associations with BMD, confirmed across multiple models.
  • Non-linear effects and threshold effects were observed for isopentanaldehyde and propanaldehyde concerning femoral BMD in men.

Conclusions:

  • Specific aldehydes, notably hexanaldehyde and propanaldehyde, negatively impact BMD in men.
  • The findings suggest that regulating hexanaldehyde and propanaldehyde could be a strategy for osteoporosis prevention.
  • This study offers new perspectives for osteoporosis prevention and treatment by highlighting the role of environmental aldehydes.