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A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals.

Xiaofeng Zhu1,2,3,4, Jiong Zhu5, Yongyi Wang6

  • 1Department of Preventive Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, No. 380 Kangding Road, 200040, Shanghai, China.

BMC Ophthalmology
|November 30, 2022
PubMed
Summary

Moderate coffee consumption acutely decreases macular retinal capillary perfusion and cerebral blood flow (CBF) in healthy individuals. However, it significantly increases retina-choroid blood flow, highlighting complex vascular effects.

Keywords:
Caffeine consumptionMagnetic resonance imagingRetinal capillary perfusionRetinal microcirculationSpectral-domain optical coherence tomography angiography

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Area of Science:

  • Ophthalmology
  • Cardiovascular Science
  • Neuroscience

Background:

  • Quantitative evidence on the acute effects of moderate coffee consumption on retinal perfusion is limited and conflicting.
  • Coffee is a widely consumed beverage across diverse populations and cultures.
  • Understanding coffee's impact on ocular microcirculation is crucial for public health.

Purpose of the Study:

  • To investigate the acute effects of moderate coffee intake on macular retinal capillary perfusion in young, healthy individuals.
  • To assess changes in cerebral blood flow (CBF) and retina-choroid blood flow following coffee consumption.

Main Methods:

  • A randomized, cross-over, and parallel-group study design involving 27 healthy participants.
  • Retinal microvasculature assessed using spectral-domain optical coherence tomography angiography (SD-OCTA).
  • Cerebral blood flow (CBF) and retina-choroid blood flow evaluated using magnetic resonance imaging (MRI) with pseudo-continuous arterial spin labeling.

Main Results:

  • Coffee intake led to a significant decrease in retinal vessel diameter index (VDI) and frontal lobe CBF 2 hours post-consumption.
  • Retina-choroid blood flow significantly increased at 0.5 and 2 hours after coffee intake.
  • Blood caffeine levels increased significantly 2 hours after coffee consumption.

Conclusions:

  • This study provides novel insights into the acute vascular effects of moderate coffee consumption using SD-OCTA and MRI.
  • Moderate coffee intake acutely reduces macular retinal capillary perfusion and CBF.
  • Coffee consumption significantly enhances retina-choroid blood flow, indicating complex cerebro-ocular hemodynamic responses.